覆盖婴幼儿脑发育障碍、自闭症、多动症,青少年焦虑、抑郁等情感障碍,成年人焦虑、抑郁及认知下降,以及老年抑郁、痴呆、帕金森病等疾病。
To cover developmental disorders of infantile brains, autism spectrum disorder, ADHD, adolescent emotional disorders, adult cognitive decline, as well as elderly depression, dementia, Parkinson's disease and other diseases.
针对免疫、躯体和代谢性疾病继发产生的认知损伤、精神异常等并发症,开展专业干预与调理服务。
Provide professional intervention and regulation for cognitive impairment and mental abnormalities caused by immune, physical and metabolic diseases.
运用人工智能技术,提升海洋活性物质筛选、作用机制研究和产品开发整体效率,搭建智能化研发体系。
To adopt artificial intelligent technology to improve the efficiency of marine active substance, mechanistic study and product development, and build an intelligent R&D system.
搭建标准化精神神经疾病的细胞、动物模式研究平台,用于药效、毒理与发病机制的验证。
Standardized cellular and animal platforms for studying efficacy, toxicity and pathogenesis verification of neuropsychiatric disorders.
干细胞体外分化构建类脑器官,高度模拟人脑生理结构,实现人体同源药物筛选。
To build up brain organoids by differentiated stem cells, which highly simulate the physiological structure of the human brain and realize human homologous medicine screenings.
高通量斑马鱼精神神经疾病筛选体系,快速评估天然产物对儿童神经遗传发育障碍、青少年及成人情感、睡眠障碍,老年认知损伤等精神障碍的干预效果。
A high-throughput zebrafish screening system to rapidly evaluate interventions for neurodevelopmental genetic disorders in children, emotional and sleep disorders in adolescents and adults, and cognitive impairment in the elderly, as well as other related psychiatric disorders.
整合基因组学、代谢组学数据,AI智能预测活性分子,大幅缩短创新功能产品研发周期。
Integrating genomics, metabolomics and multi-omics data, the system intelligently predicts active molecules via AI, which greatly shortens the R&D cycle of innovative functional products.
世界前沿方向,非传统研发路径
World-leading frontier directions, non-traditional R&D pathways.
在神经元大规模死亡前维护脑稳态
Maintain brain homeostasis before massive neuronal death occurs
无毒、副作用
Non-toxic, no side effects
生物反应器的高效开发
Efficient development of South China Sea biological resources
原产料的生产与提纯
Production and Purification of Raw Materials
产学研转化应用
Industry-University-Research Transformation and Applicatio
疾病模型的精准构建
Precise construction of disease models
高通量药物筛选平台
High-throughput drug screening platform
跨物种机制验证
Cross-species mechanism verification
利用人干细胞分化人类脑,创立神经精神疾病模型更接近人类的生理和病理
By using differentiated human stem cells to build models closer to human physiology & pathology of psychiatric and neurodegenerative diseases
高通量海洋活性物质筛选、精准靶向药物评估与毒性预测
High-throughput screened marine active substances, to targeted drug evaluation & toxicity prediction
个性化保健品配方设计功能验证、动态调控以及深入研究其对类脑器官发育和功能的作用
To personally design health product formula, verify function & dynamic regulation and in-depth study their effect on brain organoid development and function
相关靶点的识别:利用AI技术分析大量的生物学数据,包括基因组学和蛋白质组学数据,以识别与疾病相关的靶点。
Relevant targets of identifications: To utilize AI technique analyze massive biological data including genomics and proteomics data and identify disease-related targets.
结构-活性关系(SAR)建模:利用AI模型识别化合物的化学结构与其生物活性之间的关系,帮助优化药物候选物,设计出具有理想特性的新分子。
To set up structure-activity Relationship (SAR) : Using AI models to establish the correlation between compound chemical structure and biological activity, and assist optimization of drug candidates and designation of new molecules with ideal properties.
已发表SCI研究论文250篇,包括与产品相关SCI论文40篇(世界顶尖科学杂志影响因子4~34.5)
Published 250 SCI papers,including more than 40 product-related SCI papers Impact Factor (IF) of world top scientific journals ranges from 4 to 34.7
产品已获批10项专利
10 invention patents have been approved for products
荣获国家级、省部级奖项 2项
Honored 2 national and provincial Science and Technology Award
欧洲科学院院士,拥有俄罗斯科学院教授头衔; 俄罗斯政府“促进科学和教育”奖章(2022年); 俄罗斯各学科 前50名科学家之一; 高被引学者(按 Elsevier 学术排名); 斑马鱼领域全球前 0.03%(第10名)学者; 药学领域前 0.05%(按 ScholarGPS 学术排名); 俄罗斯“被引用次数最多”的神经科学家第一名(2022-2024年); 斯坦福大学 2023-2024 年学术排名列为全球前 2% 的科学家之一; 长期从事各种脑疾病动物模型的机制和研发。
Member of the European Academy of Sciences and Professor of the Russian Academy of Sciences. Recipient of the Russian Government Medal "For the Advancement of Science and Education" (2022). Ranked among the Top 50 Scientists across all disciplines in Russia. Highly Cited Researcher (per Elsevier rankings). Ranked in the top 0.03% worldwide (10th) in the field of zebrafish research. Ranked in the top 0.05% in pharmaceutical research (per ScholarGPS rankings). Ranked the No.1 Most-Cited Neuroscientistthe No.1 Most-Cited Neuroscientist in Russia (2022–2024). Listed among the Top 2% Scientists the Top 2% Scientists Worldwide by Stanford University (2023–2024). He has long been engaged in research on the mechanisms and development of animal models for various brain diseases.
俄罗斯国家工程院外籍院士; 美国昆泰跨国公司第一任大中国区董事长; 昆翎医药发展有限公司创始人兼CSO; 担任百华协会(Bayhelix)董事; 曾任美国华人生物医药科技协会会长; 美中药协执行董事; “千人计划”专家联谊会秘书长; 中国医药创新促进会药物研发专业委员会主任委员(第一届) 同时任国家“十一五“,”十二五”及“十三五”重大新药创制计划评审专家, 并参与国家食品药品监督管理总局药审中心的技术指南制订,新药临床评审及药审人员培训工作。
Foreign Member of the Russian Academy of Engineering Former First Chairman of Greater China Region at Quintiles Transnational Founder & CSO of Clinchoice (Tianjin) Pharmaceutical Development Co., Ltd. Serves as a Director of Bayhelix. Former President of Chinese Biopharmaceutical Association, USA (CBA). Executive Director of Sino-American Pharmaceutical Professionals Association (SAPA). Secretary of the Expert Association underthe "Thousand Talents Plan" . Chairman of the Drug Research and Development Committee (1st Session), China Pharmaceutical Innovation and Research Development Association. He also served as a review expert for the National Major New Drug Creation Program during the Eleventh, Twelfth and Thirteenth Five-Year Plans. He participated in the formulation of technical guidelines, clinical review of new drugs, and training of drug review staff at the Center for Drug Evaluation of the China Food and Drug Administration
加拿大健康科学院院士(FCAHS); 加拿大皇家医师协会执业医师(FRCPC); 萨大医学院神经精神研究所主任,终身教授; 2002 年获得 I. J. Small Indiana 杰出教授称号; 加拿大阿尔伯塔大学医学与牙科学院系主任; AHS 讲习教授和中国科研 合作项目院长特别顾问; 2018 年任助理院长; 2020 年任国际事务副院长。专注于精神病学临床和神经药理学领 域的研究,发表了近 200 篇论文,拥有 4 项发明专利,在精神病学和神经药理学领域做出了重要贡献。
Fellow of the Canadian Academy of Health Sciences(FCAHS). Licentiate of the Royal College of Physicians of Canada((FRCPC). The director of Neuroscience & Mental Health Institute, University of Saskatchewan, Tenured Professor. Awarded the title of Distinguished Professor of I. J. Small Indiana in 2002; Chair, Faculty of Medicine & Dentistry, University of Alberta. He is also an AHS Distinguished Visiting Professor & Special Advisor to the Dean for China Research Collaboration Programs. Served as Assistant Dean in 2018 and Vice Dean of International Affairs starting in 2020. His research focuses on clinical psychiatry and neuropharmacology. He has published nearly 200 papers and holds 4 invention patents, making significant contributions to the fields of psychiatry and neuropharmacology.
曾任中国海洋大学特聘教授; 国家千人计划特聘专家; 国家海洋实验室人才卓越科学博导。 承担包括国家重大新药创制科技重大专项在内的各类纵向课题数十项,累计获批经费约1700万元。 在抗糖尿病药物开发方面的突破,被美国诺华(Novartis)药业斥资1.57亿美元收购,并进入临床实验。此外,抗肿瘤一类新药 SL01、抗肿瘤海洋I类新药MBRI-001及I类抗慢性结肠炎新药MBRI-003项目的研发均获得了国家及青岛市重大创新基金支持国家及青岛市重大创新基金支持,并进行临床前或临床中研究。
He served as a distinguished professor at the Ocean University of China; Special Invited Expert of the National Thousand Talents Plan; National Marine Laboratory Outstanding Talent Scientific Supervisor. He has undertaken dozens of vertical projects, including the National Major Science and Technology Project for New Drug Innovation, with cumulative approved funding reaching approximately 17 million yuan. The breakthrough in the development of anti-diabetic drugs was acquired by Novartis Pharmaceuticals in the U.S. for $157 million and proceeded to clinical trials. Additionally, the research and development of new Category I anti-tumor drugs SL01, new Category I marine anti-tumor drugs MBRI-001, and new Category I drugs MBRI-003 for chronic colitis were supported by the National and Qingdao Major Innovation Funds, with preclinical or clinical studies underway.
曾任美国莫里尼亚生物制药公司研究员、广西药用植物研究所药用资源开发中心首席专家、北京亿利生物工程技术研究所所长、美国基尼盖茨公司CTO,国家千人计划生物医药领军人物;获国家药监局签发的新药证书、新药临床批件、医疗器械注册证25项,申请国家发明专利70余项,承担科技部中小企业创新基金2项、国家发改委国家产业化示范工程2项、参与起草1项国家行业标准,并有多项国外、国内填补空白项目。
He has served as a Professor at Morinaga Biopharmaceutical Company in the U.S., outstanding Professor of the Medicinal Resources Development Center at Guangxi Institute of Medicinal Plant Research, director of Beijing Yili Biotechnology Engineering Institute, and CTO of Genie Gates Company in the U.S. He is a leading scientist in the biopharmaceutical field under the National Thousand Talents Program. He has obtained 25 new drug certificates, clinical approval documents for new drugs, and medical device registration certificates issued by the National Medical Products Administration, applied for over 70 national invention patents, undertaken two projects under the Ministry of Science and Technology's Small and Medium Enterprise Innovation Fund, two national industrialization demonstration projects under the National Development and Reform Commission, participated in drafting one national industry standard, and led multiple projects that filled domestic and international gaps.